Use of recombinant human bone morphogenetic protein-2 in spine surgery
نویسندگان
چکیده
منابع مشابه
Use of recombinant human bone morphogenetic protein-2 in spine surgery
Bone morphogenetic proteins are osteoinductive factors which have gained popularity in orthopaedic surgery and especially in spine surgery. The use of recombinant human bone morphogenetic protein-2 has been officially approved by the United States Food and Drug Administration only for single level anterior lumbar interbody fusion, nevertheless it is widely used by many surgeons with off-label i...
متن کاملThe use of bone morphogenetic protein in lumbar spine surgery.
Creating a solid lumbar spinal fusion remains a challenge. Despite advances in fixation, a pseudarthrosis still may occur. Recently, attention has focused on creating a more biologically favorable environment to enhance fusion rate. Bone morphogenetic proteins (BMPs) are a group of secreted growth factors that belong to the transforming growth factor-beta superfamily. Two recombinant BMP protei...
متن کاملThe Risk of Cancer With the Use of Recombinant Human Bone Morphogenetic Protein in Spine Fusion.
STUDY DESIGN Retrospective cohort study using the Washington State Comprehensive Hospital Abstract Reporting System, the Washington State Cancer Registry, and Washington State death certificates. OBJECTIVE To study the possible association between recombinant human bone morphogenetic protein (rhBMP) and cancer risk. SUMMARY OF BACKGROUND DATA The use of rhBMP in spine fusion surgery remains...
متن کاملThe use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillofacial trauma
In recent years, recombinant human bone morphogenetic protein-2 (rhBMP-2) has been introduced as a therapeutic option in the treatment of several congenital and acquired craniofacial defects. Although there have been promising clinical results, the international literature still lacks complete guidelines, including limits and indications for the use of rhBMP-2. The possible indications for rhBM...
متن کاملEffectiveness and safety of recombinant human bone morphogenetic protein-2 for adults with lumbar spine pseudarthrosis following spinal fusion surgery
OBJECTIVES We performed a systematic review of the literature to determine the safety and efficacy of bone morphogenetic protein (BMP) compared with bone graft when used specifically for revision spinal fusion surgery secondary to pseudarthrosis. METHODS The MEDLINE, EMBASE and Cochrane Library databases were searched using defined search terms. The primary outcome measure was spinal fusion, ...
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ژورنال
عنوان ژورنال: World Journal of Orthopedics
سال: 2017
ISSN: 2218-5836
DOI: 10.5312/wjo.v8.i7.531